Growth arrest-specific protein 6 (GAS6) and the protein C pathway
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چکیده
منابع مشابه
Growth arrest-specific protein 6 (GAS6) and the protein C pathway
Growth arrest-specific protein 6 (GAS6) shares a high degree of similarity with protein S (PS), a cofactor for the protein C (PC) anticoagulant pathway. PS consists of an N-terminal γ-carboxyglutamic acid (Gla) domain, a thrombin-sensitive region (TSR), four epidermal growth factor-like domains and a large C-terminal sex hormone-binding globulin-like domain. The TSR loop, which is not present i...
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BACKGROUND Growth-arrest-specific protein 6 (GAS6) is a vitamin K-dependent protein expressed by endothelial cells and leukocytes participating in cell survival, migration and proliferation and involved in many pathological situations. The aim of our study was to assess its implication in ARDS and its variation according to PEEP setting, considering that different cyclic stresses could alter GA...
متن کاملGrowth arrest-specific protein 6 plasma concentrations during septic shock
INTRODUCTION The product of growth arrest-specific gene 6 (Gas6) is a vitamin K dependent protein that is secreted by leucocytes and endothelial cells in response to injury and participates in cell survival, proliferation, migration and adhesion. Our purpose was to investigate plasma Gas6 concentration and its relation to organ dysfunction in patients with septic shock. METHODS Forty-five pat...
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Growth arrest-specific protein 6 (Gas6) belongs to a family of vitamin K-dependent coagulation proteins. Plasma levels of Gas6 are associated to altered glucose tolerance. This study aimed at determining whether c.843+7G>A Gas6 polymorphism is associated with the development of type 2 diabetes mellitus. The study included 50 patients with type 2 diabetes and 40 matched controls. The Gas6 protei...
متن کاملUnderstanding the functional difference between growth arrest-specific protein 6 and protein S: an evolutionary approach
Although protein S (PROS1) and growth arrest-specific protein 6 (GAS6) proteins are homologous with a high degree of structural similarity, they are functionally different. The objectives of this study were to identify the evolutionary origins from which these functional differences arose. Bioinformatics methods were used to estimate the evolutionary divergence time and to detect the amino acid...
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ژورنال
عنوان ژورنال: Critical Care
سال: 2007
ISSN: 1364-8535
DOI: 10.1186/cc5734